<p>Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor</p>
0303 health sciences
03 medical and health sciences
non-small-cell lung carcinoma (NSCLC)
Cancer Management and Research
berberine
miR-19a
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
tissue factor (TF)
MAPK.
Original Research
3. Good health
DOI:
10.2147/cmar.s207677
Publication Date:
2019-10-20T23:35:26Z
AUTHORS (8)
ABSTRACT
Berberine (BBR) from the widely used Chinese herbal medicine Huanglian has an array of pharmacological and biochemical properties, including anti-neoplastic activity. However, the specific mechanisms underlying these properties are unknown. The aim of this study was to explore the anti-tumor mechanisms of BBR in non-small cell lung cancer (NSCLC).The effects of BBR on NSCLC tumor development and programmed cell death were investigated both in vivo and in vitro. Luciferase reporter assays were used to determine whether tissue factor (TF) was a target of miR-19a.BBR suppressed NSCLC growth and promoted apoptosis in NSCLC cells by modulating miR-19a and TF expression. Luciferase assays showed that TF was a direct inhibitory target of miR-19a in NSCLC cells. BBR induced apoptosis through the miR-19a/TF/MAPK axis.The results suggest that BBR induces apoptosis of NSCLC cells via the miR-19a/TF/MAPK signaling pathway.
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