<p>Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor</p>

• DOI: 10.2147/cmar.s207677
• Publication Date: 2019-10-20T23:35:26Z
• Authors: Qian-qian Chen; Jia-min Shi; Zhou Ding; Qing Xia; Tian-sheng Zheng; Yan-bei Ren; Ming Li; Li-hong Fan
• Keywords: 0303 health sciences; 03 medical and health sciences; non-small-cell lung carcinoma (NSCLC); Cancer Management and Research; berberine; miR-19a; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; tissue factor (TF); MAPK.; Original Research; 3. Good health

Background: Berberine (BBR) from the widely used Chinese herbal medicine Huanglian has an array of pharmacological and biochemical properties, including anti-neoplastic activity. However, specific mechanisms underlying these properties are unknown. The aim this study was to explore anti-tumor BBR in non-small cell lung cancer (NSCLC). Methods: effects on NSCLC tumor development programmed death were investigated both vivo vitro. Luciferase reporter assays determine whether tissue factor (TF) a target miR-19a. Results: suppressed growth promoted apoptosis cells by modulating miR-19a TF expression. showed that direct inhibitory cells. induced through miR-19a/TF/MAPK axis. Conclusion: results suggest induces via signaling pathway. Keywords: non-small-cell carcinoma, NSCLC, berberine, miR-19a, factor, TF, MAPK