<p>Ten-Year Outcomes Of Intensity-Modulated Radiotherapy (IMRT) Combine With Chemotherapy Versus IMRT Alone For Stage II Nasopharyngeal Carcinoma In The Real-World Study (RWD)</p>

• DOI: 10.2147/cmar.s218842
• Publication Date: 2019-10-09T20:30:09Z
• Authors: Xing-chen Ding; Ping-ping Fan; Peng Xie; Bing-jie Fan; Jia Yang; Li-yang Jiang; Xin-bin Bai; Jin-ming Yu; Man Hu
• Keywords: T-stage

Objectives: The aim was to define the role of chemotherapy in stage II nasopharyngeal carcinoma (NPC) and identify toxicity for these patients era intensity-modulated radiotherapy (IMRT). Methods: Between January 2002 December 2013, 169 with NPC were analyzed. Of patients, 149 treated divided into three groups as follows: neoadjuvant followed by IMRT (NCT) group, concurrent (CCRT) CCRT (NC+CCRT) group. In addition, 20 received alone. We retrospectively assessed 10-year survival acute adverse effects using SPSS software. Results: median follow-up time 93 months (2–160 months). OS NCT, CCRT, NC+CCRT vs alone group 69.8%, 63.4%, 69.7% 72.4%, respectively ( P= 0.664, 0.940, 0.998, respectively). Both univariable multivariable analyses showed that addition did not significantly improve outcomes. hematotoxicity mucous reaction more serious than those P =0.007 0.049). Distant metastasis mostly occurred within 3 years, which is very different from advanced NPC. Conclusion: Patients who are may obtain satisfactory long-term additional cannot increase survival; however, it remarkably treatment-associated toxic reactions. Keywords: carcinoma, NPC, radiotherapy, IMRT,