<p>Common molecular markers between circulating tumor cells and blood exosomes in colorectal cancer: a systematic and analytical review</p>

• DOI: 10.2147/cmar.s219699
• Publication Date: 2019-09-24T21:32:28Z
• Authors: Somayeh Vafaei; Fahimeh Fattahi; Marzieh Ebrahimi; Leila Janani; Ahmad Shariftabrizi; Zahra Madjd
• Keywords: Circulating tumor cell

Nearly half of patients with colorectal cancer (CRC), the third leading cause deaths worldwide, are diagnosed in late stages disease. Appropriate treatment is not applied a timely manner and nearly 90% who experience metastasis ultimately die. Timely detection CRC can increase five-year survival rate patients. Existing histopathological molecular classifications insufficient for prediction metastasis, which limits approaches to treatment. Detection reliable cancer-related biomarkers improve early diagnosis, prognosis, response recurrence risk. Circulating tumor cells (CTCs) exosomes peripheral blood be used liquid biopsy assess status tumor. Exosomes abundant available all fluids body, have high half-life released by most cells. Tumor-derived from primary tumors or CTCs selective cargo that represents overall The current systematic review highlights new trends determine signatures using CTC exosomes. When these combined, they could guide pathology revolutionize tools. Relevant observational studies published until July 24, 2019 evaluated expression markers were searched PubMed, Scopus, Embase, ISI Web Science databases. extracted analyzed String EnrichR