<p>miR-100-5p Inhibits Malignant Behavior of Chordoma Cells by Targeting IGF1R</p>
Chordoma
DOI:
10.2147/cmar.s252185
Publication Date:
2020-06-01T22:59:18Z
AUTHORS (11)
ABSTRACT
Our research aimed to illuminate the role of miR-100-5p in chordoma and potential mechanism.We used microRNA array analysis explore differentially expressed miRNAs tissue then verified by qRT-PCR. Cell proliferation transwell assay were evaluate function miR-100-5p. apoptosis was analyzed flow cytometry, using biological software, we predicted that insulin-like growth factor 1 receptor (IGF1R) could be target gene miR-100-5p, which validated dual luciferase assays Western blot.miR-100-5p downregulated tissues. Overexpression suppress both vitro vivo, inhibit migration invasion cells partially suppressing epithelial-mesenchymal transition (EMT). Furthermore, IGF1R as most tissues.In conclusion, our results showed lowly inhibited tumor malignant progression targeting IGF1R.
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