Clinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma

• DOI: 10.2147/cmar.s295927
• Publication Date: 2021-03-04T19:51:17Z
• Authors: Qiang Zhao; Congxiu Miao; Qingpu Lu; Weipeng Wu; Yuan He; Shouxin Wu; Huimin Liu; Changhong Lian
• Keywords: Clinical Significance

Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal cancer in China and has an extremely poor prognosis. Circulating free DNA (cfDNA) plasma heat shock protein 90alpha (Hsp90a) are two novel noninvasive biomarkers for diagnosis prognostic prediction several types cancer. However, to best our knowledge, roles ESCC still unknown.Here, we recruited 93 primary patients detected concentrations markers at different time points, including 1-3 days pre-chemotherapy, 1-7 pre-surgery 7-14 post-surgery. Baseline were associated with main characteristics which collected first diagnosis. Correlation between traditional serum baseline was also examined. Furthermore, dynamic changes cfDNA Hsp90α among points potential clinical significance assessed.Consequently, there no significant association features. Especially, demonstrated stronger correlation other circulating than level. Importantly, both significantly increased after surgery. Kaplan-Meier survival analysis showed that a change concentration (ΔcfDNA) but not (ΔHSP90ɑ) post-surgery had effect on overall surgical ESCC.Thus, ΔcfDNA evaluation could be promising marker patients. Our findings may improve understanding function ESCC.