DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

• DOI: 10.2147/cmar.s456548
• Publication Date: 2024-06-25T11:45:21Z
• Authors: Li-Mian Song; Du-Juan Yao; Lin Xia; Xu-Ming Wang; Tian Liu; Qian-Qian Tang; Jun Zhou
• Keywords: HeLa

Purpose: To explore the effect of DSG2 on growth cervical cancer cells and its possible regulatory mechanism. Methods: The expression levels survival prognosis ADAM17 in squamous cell carcinoma tissues adjacent normal were analyzed by bioinformatics. CCK-8 assay, colony formation assay Transwell used to detect effects proliferative activity, ability migration SiHa Hela cells. DSG 2 level transcription translation was detected qPCR Western blot experiments. interaction between c-MYC immunocoprecipitation. inhibitors HeLa overexpressing analyze proliferation, cells, as well regulation expression. Results: highly expressed compared with (P< 0.05), high suggested poor overall 0.05). After knockdown, significantly decreased Compared tissues, patients results immunocoprecipitation showed c-MYC. overexpression group, combined inhibition group (P < Conclusion: is cancer, can reduce proliferation which may be related through interaction. Keywords: migration, DSG2, c-MYC,