<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

• DOI: 10.2147/copd.s147688
• Publication Date: 2018-02-15T17:35:34Z
• Authors: Juan Manuel Resén...; Enrique Ambrocio-...; Gloria Pérez-Rubio; Luis Alberto Lope...; Edgar Abarca-Rojano; Gandhi Fernando P...; Fernando Flores-T...; Rafael de Jesús H...; Angel Camarena; Martha Esthela Pé...; Ana María Salazar; Alejandra Ramírez...; Ramcés Falfán-Val...
• Keywords: Mexico city; Tobacco smoke

Smoking and smoke from biomass burning (BB) are the main environmental risk factors for COPD. Clinical differences have been described between COPD related to smoking wood smoke, but no studies shown genetic patients exposed these two factors.To investigate a possible association of tumor necrosis factor (TNF) promoter polymorphisms, we conducted case-control study. A total 1,322 subjects were included in four groups: with diagnosis secondary (COPD-S, n=384), (COPD-BB, n=168), smokers without (SWOC, n=674), burning-exposed (BBES n=96). Additionally, group 950 Mexican mestizos (MMs) was as population control. Three single nucleotide polymorphisms (SNPs) selected TNF gene (rs1800629, rs361525, rs1800750) one SNP lymphotoxin alpha (rs909253).Statistically significant found genotype GA rs1800629: COPD-S vs SWOC, (p<0.001, odds ratio [OR] =2.55, 95% CI=1.53-4.27); COPD-BB (p,0.01). When performing comparison less severe (G1: I + II) more (G2: III IV) levels, identified G1 (p<0.05, OR=1.94, CI=1.04-3.63) G2 OR=3.68, CI=1.94-3.07) compared SWOC. Regarding it has associated when comparing BBES (p=0.0079, OR=5.99, CI=1.38-53.98).The heterozygous rs1800629 rs361525