Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease

• DOI: 10.2147/copd.s157035
• Publication Date: 2018-04-23T20:25:54Z
• Authors: Rie Tanaka; Hisatoshi Sugiura; Mitsuhiro Yamada; Tomohiro Ichikawa; Akira Koarai; Naoya Fujino; Satoru Yanagisawa; Katsuhiro Onodera; Tadahisa Numakura; Kei Sato; Yorihiko Kyogoku; Hirohito Sano; Shun Yamanaka; Tatsuma Okazaki; Tsutomu Tamada; Motohiko Miura; Tsuneyuki Takahashi; Masakazu Ichinose
• Keywords: Pathogenesis; Pathophysiology; Plasma levels; Growth differentiation factor

Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease Rie Tanaka,1 Hisatoshi Sugiura,1 Mitsuhiro Yamada,1 Tomohiro Ichikawa,1 Akira Koarai,1 Naoya Fujino,1 Satoru Yanagisawa,1 Katsuhiro Onodera,1 Tadahisa Numakura,1 Kei Sato,1 Yorihiko Kyogoku,1 Hirohito Sano,1 Shun Yamanaka,1 Tatsuma Okazaki,1 Tsutomu Tamada,1 Motohiko Miura,2 Tsuneyuki Takahashi,3 Masakazu Ichinose1 1Department of Respiratory Medicine, Tohoku University Graduate School Aoba-ku, Sendai, Japan; 2Department Rosai Hospital, 3Department Internal Medical and Pharmaceutical Wakabayashi Wakabayashi-ku, Japan Background: Growth (GDF11) reported to possess anti-aging rejuvenating effects, including muscle regeneration be highly expressed skeletal muscle. Recently, we demonstrated that the levels plasma GDF11 were COPD. However, effect circulating pathophysiology COPD remains unknown. The aim this study investigate association between various clinical parameters patients Patients methods: Eighteen ex-smokers as control subjects 70 participated current study. We measured using immunoblotting, lung function, physical activity a triaxial accelerometer, quadriceps strength, exercise capacity, systemic inflammatory markers. investigated these parameters. Results: had significant positive correlations data function. Furthermore, significantly correlated activity, capacity. Moreover, Although factors related GDF11, multiple regression analysis showed was GDF11. Conclusion: COPD, which might useful for understanding pathogenesis Clarifying relationships may reveal potentially attractive therapeutic approach via increasing Keywords: factor,