Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2

• DOI: 10.2147/copd.s276692
• Publication Date: 2021-01-04T22:07:58Z
• Authors: María Gómez Antúnez; Antonio Muiño Míguez; Alejandro David B...; Guillermo Maestro...; Daniel Monge Monge; Ramón Boixeda; Javier Ena; Carmen Mella Pérez; Juan Miguel Anton...; Carlos Lumbreras ...
• Keywords: Male; Pneumonia, Viral; coronavirus; International Journal of Chronic Obstructive Pulmonary Disease; Severe Acute Respiratory Syndrome; Diseases of the respiratory system; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; insuficiencia renal crónica; COPD; Humans; enfermedad pulmonar obstructiva crónica; Registries; Renal Insufficiency, Chronic; Pandemics; Original Research; Aged; Retrospective Studies; RC705-779; SARS-CoV-2; virus del SRAS; COVID-19; copd; síndrome respiratorio agudo grave; SARS Virus; Prognosis; 3. Good health; Coronavirus; Survival Rate; sars-cov-2; covid-19; Spain; Female

To describe the characteristics and prognosis of patients with COPD admitted to the hospital due to SARS-CoV-2 infection.The SEMI-COVID registry is an ongoing retrospective cohort comprising consecutive COVID-19 patients hospitalized in Spain since the beginning of the pandemic in March 2020. Data on demographics, clinical characteristics, comorbidities, laboratory tests, radiology, treatment, and progress are collected. Patients with COPD were selected and compared to patients without COPD. Factors associated with a poor prognosis were analyzed.Of the 10,420 patients included in the SEMI-COVID registry as of May 21, 2020, 746 (7.16%) had a diagnosis of COPD. Patients with COPD are older than those without COPD (77 years vs 68 years) and more frequently male. They have more comorbidities (hypertension, hyperlipidemia, diabetes mellitus, atrial fibrillation, heart failure, ischemic heart disease, peripheral vascular disease, kidney failure) and a higher Charlson Comorbidity Index (2 vs 1, p<0.001). The mortality rate in COPD patients was 38.3% compared to 19.2% in patients without COPD (p<0.001). Male sex, a history of hypertension, heart failure, moderate-severe chronic kidney disease, presence of cerebrovascular disease with sequelae, degenerative neurological disease, dementia, functional dependence, and a higher Charlson Comorbidity Index have been associated with increased mortality due to COVID-19 in COPD patients. Survival was higher among patients with COPD who were treated with hydroxychloroquine (87.1% vs 74.9%, p<0.001) and with macrolides (57.9% vs 50%, p<0.037). Neither prone positioning nor non-invasive mechanical ventilation, high-flow nasal cannula, or invasive mechanical ventilation were associated with a better prognosis.COPD patients admitted to the hospital with SARS-CoV-2 infection have more severe disease and a worse prognosis than non-COPD patients.