Interleukin-6 is a Strong Predictor of the Frequency of COPD Exacerbation Within 1 Year

• DOI: 10.2147/copd.s332505
• Publication Date: 2021-10-28T07:20:07Z
• Authors: Hui Huang; Xiaodong Huang; Kaojuan Zeng; Fan Deng; Changqing Lin; Wenjie Huang
• Keywords: Copd exacerbation; Vital capacity

Persistent chronic inflammation of obstructive pulmonary disease (COPD) is associated with poor outcomes and frequently results in acute exacerbation. Predicting the number exacerbations important. Because interleukin 6 (IL-6) plays an important role inducing maintaining inflammation, we sought to observe whether IL-6 measurement can predict frequency exacerbation COPD.We reviewed serum concentrations stable COPD patients from January 2016 December 2017 statistically analyzed them determine optimal threshold value exacerbations. Outpatients were then recruited between 2018 2019 grouped into a low group high according this value. We compared 1 year two groups.We data 95 patients, who had median 1.00 preceding year; 35 these no fewer than two. The concentration was 8.80 pg/mL. hs-CRP positively correlated year, assessment test (CAT) score British medical research council (mMRC) score, negatively forced expiratory volume one second as percentage predicted (FEV1%pred) FEV1/FVC% (forced vital capacity). risk factor or more year. Finally, enrolled 65 divided group; experienced frequent did group.An 14.030 pg/mL for ≥2 following