Disease Burden and Healthcare Utilization Among Patients with Chronic Obstructive Pulmonary Disease (COPD) in England

• DOI: 10.2147/copd.s336158
• Publication Date: 2022-03-02T13:20:11Z
• Authors: Leah B Sansbury; David A Lipson; Chanchal Bains; Glenn A Anley; Kieran J Rothnie; Afisi S Ismaila
• Keywords: Lama; Medical record; Regimen; Maintenance therapy

Purpose: Clinical guidelines for COPD management suggest pharmacologic treatment algorithms based on symptoms and exacerbation history. As previous research has suggested that prescribing patterns are not always aligned with these recommendations, this study investigated the burden of disease in patients receiving, persisting on, new inhaled maintenance therapy. Patients Methods: This was a retrospective observational using two linked electronic databases containing health records England. aged ≥ 35 years confirmed diagnosis COPD, who initiated respiratory regimen between January 1, 2014 December 31, 2016 (index date) were eligible inclusion. New treatments could be long-acting muscarinic antagonist (LAMA) or β 2 -agonist (LABA) monotherapy, corticosteroid (ICS)/LABA LAMA/LABA dual therapy, multiple-inhaler triple therapy (MITT; LAMA/LABA/ICS). required to have 12 months available medical history prior to, after, index date. Results: In total, 25,350 identified, 8282 (mean age: 70.9 years; 51.5% male) persisted their newly prescribed included analysis. index, 54% had moderate severe dyspnea (Medical Research Council score 3). The most common at MITT (42%), followed by ICS/LABA (31.2%). proportion post-index period ranged from 29.0% receiving ICS 64.2% MITT. period, 48.1% experienced 1 54.9% 5 general practitioner visits. Conclusion: Many our continued experience exacerbations, despite same months. suggests some may benefit modification accordance guideline recommendations. Keywords: chronic obstructive pulmonary disease, healthcare utilization, practice