Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease

• DOI: 10.2147/copd.s356797
• Publication Date: 2022-05-05T07:40:23Z
• Authors: Huajing Yang; Zihui Wang; Shan Xiao; Cuiqiong Dai; Xiang Wen; Fan Wu; Jieqi Peng; Heshan Tian; Yumin Zhou; Pixin Ran
• Keywords: Vital capacity; Obstructive lung disease

The effect of serum uric acid (SUA) levels on lung function in chronic obstructive pulmonary disease (COPD) people remained unclear. We aimed to investigate the association between SUA and function.A cross-sectional study was performed measure 2797 consecutive eligible individuals. Of these, individuals our were divided into two groups, COPD group (n=1387) non-COPD (n=1410). diagnosis is defined as post-bronchodilator first second forced expiratory volume (FEV1)/forced vital capacity (FVC) ratio less than 0.70. Multivariable adjustment linear models applied estimate FEV1% predicted, FVC% FEV1/FVC stratified by status.After multivariable adjustment, each 1 mg/dL increase significantly associated with a decrease predicted (-1.63%, 95% confidence interval [CI] -2.37 -0.90), FVC % (-0.89%, CI -1.55 -0.24), (-0.70%, -1.10 -0.30). In group, decreases (-1.87%, -2.91 -0.84), (-1.35%, -2.35 -0.34), (-0.63%, -1.18 -0.08). However, no significant found among without COPD.High lower function, especially patients. statistically COPD.