Pulmonary function impairment in patients with combined pulmonary fibrosis and emphysema with and without airflow obstruction

• DOI: 10.2147/copd.s65621
• Publication Date: 2014-07-29T19:20:28Z
• Authors: Yoshiaki Kitaguchi; Keisaku Fujimoto; Masayuki Hanaoka; Takayuki Honda; Junichi Hotta; Jiro Hirayama
• Keywords: Male; Pulmonary Fibrosis; Vital Capacity; International Journal of Chronic Obstructive Pulmonary Disease; Severity of Illness Index; Diseases of the respiratory system; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Forced Expiratory Volume; Humans; Lung; Original Research; Aged; Retrospective Studies; RC705-779; Syndrome; 3. Good health; Phenotype; Pulmonary Emphysema; Spirometry; Pulmonary Diffusing Capacity; Female; Tomography, X-Ray Computed

Background: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is a recently described entity associating upper-lobe lower-lobe fibrosis. We sought to evaluate differences in function between CPFE patients with without airflow obstruction. Subjects methods: Thirty-one were divided into two groups according the presence or absence irreversible obstruction based on spirometry (forced expiratory volume 1 second/forced vital capacity <70% following inhalation β 2 -agonist) as follows: (CPFE OB + group, n=11), – n=20). Pulmonary function, including respiratory impedance evaluated using impulse oscillometry dynamic hyperinflation metronome-paced incremental hyperventilation, was retrospectively analyzed comparison that observed 49 chronic obstructive disease (COPD) (n=49). Results: In imaging findings, low-attenuation-area scores chest high-resolution computed tomography, representing degree emphysema, significantly lower group than COPD groups. contrast, severity greater group. lung not apparent Impairment diffusion severe both Impulse showed resistance compared easy collapsibility small airways during expiration tidal breath Dynamic hyperventilation also tended be Conclusion: mechanisms underlying impairment physiological may differ among patients, patients. heterogeneous disease, have distinct phenotypes physiologically radiologically. Keywords: CPFE, COPD, impedance,