<p>Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study</p>

• DOI: 10.2147/dddt.s202410
• Publication Date: 2019-07-02T23:37:56Z
• Authors: Nguyen Trung Kien; Phillip Geiger; Hoang Van Chuong; Nguyen Manh Cuong; Ngo Van Dinh; Dinh Cong Pho; Vu The Anh; Nguyen Truong Giang
• Keywords: Adult; Male; Analgesics; Drug Design, Development and Therapy; Lumbar Vertebrae; Morphine; Pregabalin; Administration, Oral; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Celecoxib; Humans; Female; Prospective Studies; Original Research

To evaluate the preemptive analgesic effect of combination pregabalin with celecoxib for lumbar spine surgery.A prospective, randomized study was conducted among 60 lumbar spine surgery patients and divided into two groups. Postoperative pain relief was achieved with intravenous patient-controlled analgesia with morphine. The preemptive analgesia group received oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery, and the control group received a placebo. Pain was assessed by visual analogue scale (VAS). Side effects and morphine consumption were monitored until 48 hrs after surgery.VAS score at rest and during movement was statistically significantly lower in the preemptive analgesia group at most time points (p<0.05). Morphine consumption was significantly lower in the preemptive analgesia group compared with control group in the 24 first hours (29.03±4.38 mg vs 24.43±4.94) and 48 hrs (52.23±9.57 mg vs 44.20±10.21 mg), p<0.05. Hemodynamics, respiratory rate, and SpO2 were similar for both groups. The sedation score was only statistically significant at H8 time point. The incidence of nausea/vomiting in the preemptive group did not statistically differ from the control group.Preoperative administration of pregabalin combined with celecoxib had a good preemptive analgesia effect and reduced intravenous morphine consumption after lumbar spine surgery. Side effects were mild and transient.