<p>A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study</p>

• DOI: 10.2147/dddt.s203464
• Publication Date: 2019-07-17T21:14:19Z
• Authors: Jiarui Yang; Yushi Liu; Yanhui Xu; Xiaodan Li; Jiayu Fu; Xiaodan Jiang; Yilin Chou; Jiahui Ma; Ran Hao; Rong Zhang; Weiqiang Qiu; Xuemin Li
• Keywords: Basal (medicine)

Purpose: To present a new ocular nebulization therapy for the treatment of dry eye disease (DED) and investigate efficacy vitamin B12 (VB12) oxytocin (OXT) with clinical parameters in vivo confocal microscopy (IVCM). Patients methods: Thirty-eight patients DED were enrolled, 19 receiving VB12 OXT twice weekly 3 months. Clinical signs symptoms including Ocular Surface Disease Index, self-assessment light sensitivity dryness, tear meniscus height, break-up time (BUT), corneal staining, along IVCM data basal epithelial cell density, sub-basal dendritic (DC) nerve tortuosity acquired at baseline, 1 month, months after starting treatment. Results: treated improved significantly all except during three-month treatment, while demonstrated similar effects apart from BUT tortuosity. group revealed higher month density compared group, lower DC was observed month. Change more significant showing reduction Conclusion: The delivering appears to be effective improving eye, relatively stronger effect elevation repair anti-inflammation nebulization. Keywords: microscopy, nebulization, oxytocin,