Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus

• DOI: 10.2147/dmso.s344532
• Publication Date: 2022-01-05T18:10:35Z
• Authors: Tuan Dinh Le; Nga Phi Thi Nguyen; Thi Thanh Hoa Tran; Thuc Luong Cong; Lan Ho Thi Nguyen; Binh Do Nhu; Son Tien Nguyen; Manh Van Ngo; Trung Hoa Dinh; Hien Thi Nguyen; Kien Trung Nguyen; Cuong Duc Le
• Keywords: cardiovascular risk factors; 03 medical and health sciences; 0302 clinical medicine; glucagon-like peptide-1 concentrations; RC581-951; newly-diagnosed type 2 diabetes mellitus; diabetic peripheral neuropathy; Specialties of internal medicine; Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity]; Original Research; 3. Good health

Purpose: This study was aimed at the prevalence, cardiovascular risk factors of diabetic peripheral neuropathy (DPN), and relationship between DPN fasting glucagon-like peptide-1 (fGLP-1) concentrations in newly diagnosed patients with type 2 diabetes mellitus (nT2D). Methods: A cross-sectional descriptive conducted from 2015 to 2020 a population 473 nT2D. Screening for based on United Kingdom screening test. fGLP-1 measured by enzyme-linked immunosorbent assay. Results: The prevalence 26.6%, which mild grade 17.3%, moderate 8.2% severe 1.1% total. Age (OR = 1.73, 95% CI 1.12– 2.67, p 0.012), smoking 1.64, 1.03– 2.62, 0.037), poor control HbA1c 2.66, 1.23– 5.76, 0.01), 24-h urinary albumin (24hUA) 2.49, 1.26– 4.94, 0.007), retinopathy 3.17, 1.46– 6.89, 0.002) significantly increased DPN. In multivariate logistic regression analysis, hypertension 2.96, 1.16– 7.55, 0.023), triglyceride 1.50, 1.11– 2.03, 0.009), 0.85, 0.75– 0.95, 0.005), 0.79, 0.67– 0.93, 0.005) correlated were reduced (p < 0.001). particular, male had lower levels than those without Conclusion: among nT2D 26.6%. Age, smoking, hypertension, control, triglyceride, albumin, 24hUA, associated DPN, negatively 0.005). Keywords: mellitus, neuropathy, factors,