The Correlation between Thyroid Hormone Levels and the Kidney Disease Progression Risk in Patients with Type 2 Diabetes

• DOI: 10.2147/dmso.s347862
• Publication Date: 2022-01-05T10:40:09Z
• Authors: Zhi Yang; Peng Duan; Weihong Li; Ronghui Nie; Xiaoyang Lou; Lina Wang; Kexia Wu; Jiang Liu; Ping Tu; Xiaoyang Lai
• Keywords: Subclinical infection; Albuminuria; Thyroid-stimulating hormone

Objective: We investigated the relationship between thyroid hormones and risk of diabetic kidney disease (DKD) progression. Methods: A total 452 patients with type 2 diabetes were included, a cross-sectional analysis was performed. Urine albumin/creatinine ratio (ACR) estimated glomerular filtration rate (eGFR) used to diagnose persistent albuminuria stage chronic disease, respectively. The Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline describe DKD progression (low, moderate, high or very risks). Results: group had higher levels thyroid-stimulating hormone (TSH) lower free triiodothyronine (FT 3 ) thyroxine 4 than non-DKD group. prevalence dysfunction in significantly group, especially subclinical hypothyroidism. FT decreased gradually deterioration DKD. TSH increased an increasing KDIGO category. negatively correlated serum creatinine ACR, positively eGFR. Contrastingly, After adjustment, increase reduced [odds ratio, OR (95% confidence interval, CI)=0.58 (0.42– 0.79)] [ORs CIs)=0.65 (0.45– 0.93) for moderate 0.50 (0.33– 0.74) high-risk using low-risk as reference]. below 4.30 pmol/L men 3.99 women cut-off points Conclusion: Low level is independent factor ≤ will greatly diabetes. Keywords: hormone, prognosis mellitus