Free Triiodothyronine Levels are Related to Executive Function and Scene Memory in Type 2 Diabetes Mellitus Patients Without Diagnosed Thyroid Diseases

• DOI: 10.2147/dmso.s355656
• Publication Date: 2022-04-05T09:41:26Z
• Authors: Haoqiang Zhang; Shufang Yang; Wenwen Zhu; Tong Niu; Zheng Wang; Ke An; Zuoling Xie; Pin Wang; Xi Huang; Chenchen Wang; Haiyan Shangguan; Yang Yuan; Shaohua Wang
• Keywords: Memory span; Trail Making Test; Verbal fluency test

We aim to determine the role of free triiodothyronine (FT3), main active ingredient thyroid hormones (THs), in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment (MCI).A total 255 T2DM without diagnosed diseases were recruited and divided into MCI group healthy cognition group. Neuropsychological functions observed by multidimensional function scales including MoCA, Digit Span Test (DST), Verbal Fluency (VFT), Clock drawing test (CDT), Trail Making (TMT) A B, Instantaneously Recalled Auditory Learning (AVLT-IR), Delayed (AVLT-DR) Logical Memory (LMT). Correlation logistic regression analyses performed explore association between FT3 diabetic dysfunction.Compared 147 normal patients, 108 exhibited lower higher HOMA-IR. level was not only positively correlated MoCA scores, but DST, VFT LMT, while negatively associated TMTB. Furthermore, there is a negative Logistic showed that decreased risk factor patients. Although after homeostasis model assessment insulin resistance (HOMA-IR) entered as an independent variable, LMT adjusted age, education, BMI, DM duration, HBP smoking, HbA1c HOMA-IR.Lower levels may involve MCI, especially for executive scene memory diseases.