Effects of 12-Week Combined Strength and Endurance Circuit Training Program on Insulin Sensitivity and Retinol-Binding Protein 4 in Women with Insulin-Resistance and Overweight or Mild Obesity: A Randomized Controlled Trial

• DOI: 10.2147/dmso.s432954
• Publication Date: 2024-01-06T04:15:06Z
• Authors: Marzena Ratajczak; Monika Krzywicka; Monika Szulińska; Dominika Musiałowska; Krzysztof Kusy; Joanna Karolkiewicz
• Keywords: Endurance Training; Circuit training

Background: Circuit training is an exercise mode, that may include both endurance and resistance components. There are premises a combination of these two modalities brings additional benefits, particularly in improving insulin sensitivity. The retinol-binding protein 4 (RBP4) inhibit signaling from metabolic pathways skeletal muscles, thus developing resistance. This study aimed to evaluate whether moderate intensity circuit combining strength induces changes tissue sensitivity, carbohydrate lipid metabolism, serum RBP4 levels insulin-resistant women. Methods: In this clinical controlled trial women diagnosed with insulin-resistance were randomly divided into groups. group (T) performed (50%-80%1RM) (50%-75%HRR) on five weight cardio machines, for 33 minutes, three times per week, 3 months. Women the control non-training (NT) did not change their previous physical activity. At beginning after intervention period, one-repetition maximum, body mass, composition, resting heart rate (HR), blood pressure, glucose, insulin, lipids, thyroid-stimulating hormone (TSH), insulin-like growth factor-1 (IGF-1), RBP4, (HOMA-IR) measured. results 27 patients analyzed using two-way repeated measures ANOVA. Results: Significant differences pattern over time between groups HR (p < 0.010) total lean mass 0.039) found. No HOMA-IR, observed post-study compared pre-study T group. A significant correlation TSH concentration was Conclusion: Twelve-week has minor effects glucose IGF-1, TSH, RBP4. Although moderate-intensity considered safe, its effectiveness overweight mild obesity be insufficient reduce Trial Registration: ClinicalTrials.gov: NCT04528693, registered August 23, 2020. Keywords: resistance, program, 4, factors-1,