Targeted Metabolomics Analysis of Serum Amino Acids in T2DM Patients

• DOI: 10.2147/dmso.s444987
• Publication Date: 2024-01-10T08:05:06Z
• Authors: Li Bao; Bowen Wu; Chunjing Yang; Xiqiao Xu; Zhengyuan Shi; Dechun Jiang
• Keywords: 0301 basic medicine; diabetes mellitus type 2; amino acids; 03 medical and health sciences; RC581-951; Diabetes, Metabolic Syndrome and Obesity; t2dm; targeted metabolomics; biomarker; Specialties of internal medicine; Original Research

Purpose: Amino acids are the important metabolites in body and play a crucial role biological processes. The purpose of this study is to provide profile amino change serum T2DM patients identify potential biomarkers. Patients Methods: In study, we quantitatively determined acid profiles 30 healthy volunteers. T test multivariate statistical analysis were used candidate biomarkers with GraphPad Prism 9.5 software MetaboAnalyst 5.0 on-line platform. Results: Thirty-four quantified, 19 levels differed significantly between Healthy groups. Screened by specific screening criteria (VIP> 1.0; P< 0.05; FC> 1.5, or FC< 0.67) platform, 8 identified as Pearson rank correlation showed 14 differential correlated T2DM-related physiological parameters. Conclusion: results theoretical basis for subsequent development dietary supplements prevention treatment its complications. Keywords: diabetes mellitus type 2, T2DM, targeted metabolomics, acids, biomarker