Impact of Hyperglycemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study

• DOI: 10.2147/dmso.s500595
• Publication Date: 2025-02-03T07:50:10Z
• Authors: Fanhua Meng; Yuan Zhou; Tong Bao; Yunlei Pang; Qinglei Shao; Lifeng Wang; Jing Zhao; Wenchao Li; Haiyan Xu; Yajun Yang; Bozhou Zhang
• Keywords: Meibomian gland; Cross-sectional study

Purpose: Elevated blood glucose levels may disrupt tear film and meibomian gland function, contributing to dry eye disease (DED) dysfunction (MGD). This study aimed explore the relationship between hyperglycemia DED parameters. Methods: A cross-sectional at Chifeng Chaoju Eye Hospital (June–August 2024) included 56 participants with symptoms. Tear meniscus height (TMH), non-invasive breakup time (FNIBUT, ANIBUT), bulbar redness, atrophy (U-LAMG, L-LAMG) were assessed using a ocular surface analyzer. Fasting stratified patients into high (≥ 7 mmol/l) normal (< groups, their association parameters was analyzed. Results: Among (mean age 52.5 ± 18.0 years), those elevated (n=28) had more severe symptoms (OSDI, p = 0.046), lower TMH, FNIBUT, ANIBUT, higher redness scores (all < 0.05). In contrast, associated greater U-LAMG L-LAMG (p Glucose positively correlated intraocular pressure (IOP), U-LAMG, but negatively ANIBUT Conclusion: Hyperglycemia is linked impaired stability, Ocular disorders in individuals diabetes be prevented by effective glycemic control. Keywords: hyperglycemia, disease, dysfunction, height,