The Correlation Between Impaired Thyroid Hormone Sensitivity and Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes Mellitus

• DOI: 10.2147/dmso.s507750
• Publication Date: 2025-04-23T06:10:12Z
• Authors: Dengrong Ma; Pingping Zhao; Jie Gao; Xinyuan Guo; Mei Han; Xiaohui Zan; Chongyang Chen; Xiaoyu Lv; Jingfang Liu

To investigate the association between impaired thyroid hormone sensitivity and diabetic nephropathy (DN) in euthyroid patients with type 2 diabetes mellitus (T2DM). 1305 T2DM who were hospitalized Endocrinology Department of First Hospital Lanzhou University July 2021 August 2023 selected. Several indices, such as parameters feedback quantile index (PTFQI), (TFQI), stimulating (TSHI), serum-free triiodothyronine to free thyroxine (FT3/FT4) ratio, thyrotropin resistance (TT4RI) evaluate used. The subdivided into four groups (Q 1 Q 4) based on quartile levels five indices. correlation DN was analyzed by binary logistic regression restricted cubic spline (RCS) analysis. PTFQI, TFQI, TSHI group higher than those Non-DN [0.04(-0.21, 0.31) vs -0.003(-0.27, 0.25), 0.05(-0.20, 0.30) 0.006(-0.26, 2.54±0.52 2.47±0.51, all P<0.05], while FT3/FT4 decreased (0.40±0.07 0.42±0.07, P<0.05). Multivariate analysis showed that increase PTFQI TFQI positively correlated [OR=1.518, 95% CI(1.074, 2.145) OR=1.546, CI(1.084, 2.204)]. RCS a linear dose-response relationship TSHI, FT3/FT4, TT4RI, tendency (all P non-linear>0.05). As increased, decreased, prevalence urinary albumin-to-creatinine (UACR) level an upward trend Ptrend test <0.05), estimated glomerular filtration rate (eGFR) downward <0.05). Among T2DM, is associated DN, well elevated UACR eGFR levels.