Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Male 0301 basic medicine Medicine (General) Curcumin Polyesters Mice, Nude Apoptosis Biocompatible Materials Polyethylene Glycols Rats, Sprague-Dawley 03 medical and health sciences R5-920 International Journal of Nanomedicine glioma Animals Humans curcumin Micelles Original Research Cell Proliferation Drug Carriers cell apoptosis Glioma angiogenesis. Antineoplastic Agents, Phytogenic 3. Good health cell proliferation Female Drug Screening Assays, Antitumor
DOI: 10.2147/ijn.s102450 Publication Date: 2016-06-10T02:53:00Z
ABSTRACT
Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and vivo Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department Neurosurgery, West China Hospital, Medical School, Sichuan University, Chengdu, People's Republic China; 2Department Pharmacology, Yale School Medicine, New Haven, CT, USA *These authors contributed equally to this work Abstract: Curcumin (Cur), a natural polyphenol Curcuma longa, has been recently reported possess antitumor activities. However, due its poor aqueous solubility low biological availability, clinical application Cur is quite limited. The encapsulation hydrophobic drugs into nanoparticles an effective way improve their pharmaceutical In research, nanomicelles loaded with were formulated by self-assembly method biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, cellular uptake was increased could be released from MPEG-PLA sustained manner. Cur-loaded (Cur/MPEG-PLA micelles) exhibited enhanced toxicity on C6 U251 glioma cells induced more apoptosis compared free Cur. Moreover, therapy efficiency Cur/MPEG-PLA evaluated at length nude mouse model bearing glioma. suppressing tumor growth Cur, which indicated that improved vivo. results immunohistochemical immunofluorescent analysis induction apoptosis, antiangiogenesis, inhibition cell proliferation may contribute improvement effects. Our data suggested have potential clinic applications therapy. Keywords: curcumin, glioma, proliferation, angiogenesis
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