Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

• DOI: 10.2147/ijn.s102450
• Publication Date: 2016-06-10T02:53:00Z
• Authors: Xiang Xiang Gao; Songping Zheng; Ting Yu; Tianying Zheng; Xiaoxiao Liu; Yi Wang; Chao You
• Keywords: Male; 0301 basic medicine; Medicine (General); Curcumin; Polyesters; Mice, Nude; Apoptosis; Biocompatible Materials; Polyethylene Glycols; Rats, Sprague-Dawley; 03 medical and health sciences; R5-920; International Journal of Nanomedicine; glioma; Animals; Humans; curcumin; Micelles; Original Research; Cell Proliferation; Drug Carriers; cell apoptosis; Glioma; angiogenesis.; Antineoplastic Agents, Phytogenic; 3. Good health; cell proliferation; Female; Drug Screening Assays, Antitumor

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and vivo Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department Neurosurgery, West China Hospital, Medical School, Sichuan University, Chengdu, People's Republic China; 2Department Pharmacology, Yale School Medicine, New Haven, CT, USA *These authors contributed equally to this work Abstract: Curcumin (Cur), a natural polyphenol Curcuma longa, has been recently reported possess antitumor activities. However, due its poor aqueous solubility low biological availability, clinical application Cur is quite limited. The encapsulation hydrophobic drugs into nanoparticles an effective way improve their pharmaceutical In research, nanomicelles loaded with were formulated by self-assembly method biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, cellular uptake was increased could be released from MPEG-PLA sustained manner. Cur-loaded (Cur/MPEG-PLA micelles) exhibited enhanced toxicity on C6 U251 glioma cells induced more apoptosis compared free Cur. Moreover, therapy efficiency Cur/MPEG-PLA evaluated at length nude mouse model bearing glioma. suppressing tumor growth Cur, which indicated that improved vivo. results immunohistochemical immunofluorescent analysis induction apoptosis, antiangiogenesis, inhibition cell proliferation may contribute improvement effects. Our data suggested have potential clinic applications therapy. Keywords: curcumin, glioma, proliferation, angiogenesis