Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
Male
0301 basic medicine
Medicine (General)
Curcumin
Polyesters
Mice, Nude
Apoptosis
Biocompatible Materials
Polyethylene Glycols
Rats, Sprague-Dawley
03 medical and health sciences
R5-920
International Journal of Nanomedicine
glioma
Animals
Humans
curcumin
Micelles
Original Research
Cell Proliferation
Drug Carriers
0303 health sciences
cell apoptosis
Glioma
angiogenesis.
Antineoplastic Agents, Phytogenic
3. Good health
cell proliferation
Female
Drug Screening Assays, Antitumor
DOI:
10.2147/ijn.s102450
Publication Date:
2016-06-10T02:53:00Z
AUTHORS (7)
ABSTRACT
Curcumin (Cur), a natural polyphenol of Curcuma longa, has been recently reported to possess antitumor activities. However, due to its poor aqueous solubility and low biological availability, the clinical application of Cur is quite limited. The encapsulation of hydrophobic drugs into nanoparticles is an effective way to improve their pharmaceutical activities. In this research, nanomicelles loaded with Cur were formulated by a self-assembly method with biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, the cellular uptake was increased and Cur could be released from MPEG-PLA micelles in a sustained manner. The Cur-loaded MPEG-PLA micelles (Cur/MPEG-PLA micelles) exhibited an enhanced toxicity on C6 and U251 glioma cells and induced more apoptosis on C6 glioma cells compared with free Cur. Moreover, the therapy efficiency of Cur/MPEG-PLA micelles was evaluated at length on a nude mouse model bearing glioma. The Cur/MPEG-PLA micelles were more effective on suppressing tumor growth compared with free Cur, which indicated that Cur/MPEG-PLA micelles improved the antiglioma activity of Cur in vivo. The results of immunohistochemical and immunofluorescent analysis indicated that the induction of apoptosis, antiangiogenesis, and inhibition of cell proliferation may contribute to the improvement in antiglioma effects. Our data suggested that Cur/MPEG-PLA may have potential clinic applications in glioma therapy.
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