Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo
Male
0301 basic medicine
Medicine (General)
Curcumin
Polyesters
Mice, Nude
Apoptosis
Biocompatible Materials
Polyethylene Glycols
Rats, Sprague-Dawley
03 medical and health sciences
R5-920
International Journal of Nanomedicine
glioma
Animals
Humans
curcumin
Micelles
Original Research
Cell Proliferation
Drug Carriers
cell apoptosis
Glioma
angiogenesis.
Antineoplastic Agents, Phytogenic
3. Good health
cell proliferation
Female
Drug Screening Assays, Antitumor
DOI:
10.2147/ijn.s102450
Publication Date:
2016-06-10T02:53:00Z
AUTHORS (7)
ABSTRACT
Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and vivo Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department Neurosurgery, West China Hospital, Medical School, Sichuan University, Chengdu, People's Republic China; 2Department Pharmacology, Yale School Medicine, New Haven, CT, USA *These authors contributed equally to this work Abstract: Curcumin (Cur), a natural polyphenol Curcuma longa, has been recently reported possess antitumor activities. However, due its poor aqueous solubility low biological availability, clinical application Cur is quite limited. The encapsulation hydrophobic drugs into nanoparticles an effective way improve their pharmaceutical In research, nanomicelles loaded with were formulated by self-assembly method biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, cellular uptake was increased could be released from MPEG-PLA sustained manner. Cur-loaded (Cur/MPEG-PLA micelles) exhibited enhanced toxicity on C6 U251 glioma cells induced more apoptosis compared free Cur. Moreover, therapy efficiency Cur/MPEG-PLA evaluated at length nude mouse model bearing glioma. suppressing tumor growth Cur, which indicated that improved vivo. results immunohistochemical immunofluorescent analysis induction apoptosis, antiangiogenesis, inhibition cell proliferation may contribute improvement effects. Our data suggested have potential clinic applications therapy. Keywords: curcumin, glioma, proliferation, angiogenesis
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