Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity

• DOI: 10.2147/ijn.s134843
• Publication Date: 2017-06-07T20:16:25Z
• Authors: Jianfeng Jin; Li Zhang; Mengqi Shi; Yumei Zhang; Qintao Wang
• Keywords: Biocompatibility; Surface Modification; Silver nanoparticle

Ti-GO-Ag nanocomposite: the effect of content level on antimicrobial activity and cytotoxicity Jianfeng Jin,1,2 Li Zhang,3 Mengqi Shi,3 Yumei Qintao Wang11State Key Laboratory Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Engineering Dental Materials Advanced Manufacture, Department Periodontology, School Stomatology, The Fourth Medical University, Xi’an, 2Department General Dentistry, Kunming Municipal Hospital, Kunming, 3State Prosthodontics, People’s Republic China Abstract: Surface modification titanium (Ti) implants are extensively studied in order to obtain prominent biocompatibility activity, especially preventing implant-associated infection. In this study, Ti substrates surface were modified by graphene oxide (GO) thin film silver (Ag) nanoparticles via electroplating ultraviolet reduction methods so as achieve purpose. Microstructures, distribution, quantities spectral peaks GO Ag loading sheets characterized. GO-Ag-Ti multiphase nanocomposite exhibited excellent ability anti-adherence performance. Subsequently, morphology, membrane integrity, apoptosis relative genes expression bacteria incubated samples monitored reveal bactericidal mechanism. Additionally, incorporating investigated. composite configuration that have outstanding antibacterial properties will provide foundation study bone integration vitro vivo future.Keywords: nanocomposite, microstructure quantities, mechanism,