Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)&ndash;polyethylene glycol&ndash;folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

• DOI: 10.2147/ijn.s136488
• Publication Date: 2017-08-11T00:07:00Z
• Authors: Jia Chen; Qi Wu; Li Luo; Yi Wang; Yuan Zhong; Hanbin Dai; Da Sun; Maoling Luo; Wei Wu; Guixue Wang
• Keywords: Nanocarriers; PLGA; Glycolic acid

Abstract: Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic- co -glycolic acid) (PLGA)–polyethylene glycol (PEG)–folic acid (FA) copolymer was able self-assemble into nanoparticles with favorable hydrodynamic diameters around 100 nm negative surface charge aqueous solution, which expected enhance intracellular drug delivery by advanced dual tumor-target effects, ie, enhanced permeability retention induced the passive target, FA mediated positive target. Fluorescence-activated cell-sorting confocal laser-scanning microscopy results confirmed that doxorubicin (model drug) loaded PLGA-PEG-FA be delivered efficiently tumor cells accumulated at nuclei. addition, all hemolysis, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, zebrafish-development experiments demonstrated were biocompatible secure for biomedical applications, even high polymer concentration (0.1 mg/mL), both vitro vivo. Therefore, provide feasible controlled-release platform efficient delivery. Keywords: nanoparticle, security, efficient, delivery, therapy