Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

• DOI: 10.2147/ijn.s147591
• Publication Date: 2017-12-04T17:33:59Z
• Authors: Dan Wang; Sipei Zhang; Tao Zhang; Guoyun Wan; Bowei Chen; Qingqing Xiong; Jie Zhang; Wenxue Zhang; Yinsong Wang
• Keywords: Pullulan

IR780, a near-infrared dye, can also be used as photosensitizer both for photothermal therapy (PTT) and photodynamic (PDT). In this study, we designed simple but effective nanoparticle system carrying IR780 paclitaxel, thus hoping to combine PTT/PDT chemotherapy treat hepatocellular carcinoma (HCC). This nanosystem, named PDF nanoparticles, consisted of phospholipid/Pluronic F68 complex nanocores pullulan shells. paclitaxel were loaded separately into nanoparticles form PDFI PDFP which had regular sphere shapes relatively small sizes. Upon laser irradiation at 808 nm, showed strong efficacy in vitro vivo. MHCC-97H cells, the combined treatment nanoparticles/laser exhibited significant synergistic effects on inhibiting cell proliferation inducing apoptosis cycle arrest G2/M phase. tumor-bearing mice, excellent HCC-targeting accumulating capability after intravenous injection. Furthermore, effectively inhibited tumor growth angiogenesis mice. summary, put forward therapeutic strategy HCC by combining chemotherapy.