Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: evaluation of size-dependent imaging properties, storage stability and safety

• DOI: 10.2147/ijn.s156528
• Publication Date: 2018-03-27T19:14:44Z
• Authors: Harald Unterweger; László Dézsi; Jasmin Matuszak; Christina Janko; Marina Poettler; Jutta Jordan; Tobias Bäuerle; János Szebeni; Tobias Fey; Aldo Boccaccini; Christoph Alexiou; Iwona Cicha
• Keywords: Biocompatibility

Background: Rising criticism of currently available contrast agents for magnetic resonance imaging, either due to their side effects or limited possibilities in terms functional evoked the need safer and more versatile agents. We previously demonstrated suitability novel dextran-coated superparamagnetic iron oxide nanoparticles (SPION Dex ) biomedical applications safety biocompatibility. Methods: In present study, we investigated size-dependent cross-linking process these particles as well size dependency imaging properties. For latter purpose, adopted a simple easy-to-perform experiment estimate relaxivity particles. Furthermore, performed an extensive analysis particles’ storage stability under different temperature conditions, showing superb lack any signs agglomeration sedimentation during 12 week period. Results: Independent size, SPION displayed no irritation potential chick chorioallantoic membrane assay. Cell uptake studies ultra-small (30 nm) confirmed internalization by macrophages, but not non-phagocytic cells. Additionally, complement activation-related pseudoallergy (CARPA) experiments pigs treated with indicated absence hypersensitivity reactions. Conclusion: These results emphasize exceptional , setting them apart from existing SPION-based making very promising candidate further clinical development. Keywords: CARPA, cross-linking, potential, MRI, SPION,