Argon plasma improves the tissue integration and angiogenesis of subcutaneous implants by modifying surface chemistry and topography

• DOI: 10.2147/ijn.s167637
• Publication Date: 2018-10-07T20:46:06Z
• Authors: Michelle Griffin; Robert Palgrave; Víctor Baldovino-...; Peter Butler; Deepak Kalaskar
• Keywords: Surface Modification; Protein Adsorption

Background: Tissue integration and vessel formation are important criteria for the successful implantation of synthetic biomaterials subcutaneous implantation. Objective: We report optimization plasma surface modification (PSM) using argon (Ar), oxygen (O 2 ) nitrogen (N gases a polyurethane polymer to enhance tissue angiogenesis. Methods: The scaffold’s bulk characteristics were compared before after PSM with either Ar, O N . viability adhesion human dermal fibroblasts (HDFs) on modified scaffolds compared. extracellular matrix by HDFs was evaluated. Scaffolds subcutaneously implanted in mouse model 3 months analyze integration, angiogenesis capsule formation. Results: Surface analysis demonstrated that interfacial (chemistry, topography wettability) achieved is unique varies according gas used. led extensive changes properties, whereas Ar treatment caused moderate changes. least effect chemistry polymer. PSM-treated significantly ( P <0.05) enhanced HDF activity growth over 21 days. Among all three gases, showed highest protein adsorption. Ar-modified also significant upregulation adhesion-related proteins (vinculin, focal kinase, talin paxillin; marker genes (collagen type I, fibronectin, laminin elastin) deposition associated HDFs. Subcutaneous lowest - -modified scaffolds. Conclusion: cost-effective efficient method improve implants. Keywords: angiogenesis, modification, biomaterials, implants Corrigendum this paper has been published