Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure

• DOI: 10.2147/ijn.s177109
• Publication Date: 2018-09-26T22:45:48Z
• Authors: Meng-meng Lu; Jing Bai; Dan Shao; Jing Qiu; Ming Li; Xiao Zheng; Yun Xiao; Zheng Wang; Zhi-min Chang; Li Chen; Wen-fei Dong; Chun-bo Tang
• Keywords: Biocompatibility; Zeta potential

Although various organic tissue adhesives designed to facilitate would healing are gaining popularity in diverse clinical applications, they present significant inherent limitations, such as rejection, infections, toxicity and/or excessive swelling. It is highly desirable develop efficient, biocompatible and anti-bacterial for skin wound healing.Inspired by the fact that inorganic nanoparticles can directly glue tissues through "nanobridging effect", herein disulfide bond-bridged nanosilver-decorated mesoporous silica (Ag-MSNs) was constructed an effective safe adhesive with antibacterial degradable properties closure healing.Ag-MSNs fabricated controlled reduce of ultrasmall nanosilvers onto both surface large pore biodegradable MSNs. The obtained MSNs were characterized transmission electron microscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray measurement size distribution, zeta potential, mesopore properties. Furthermore, adhesion strength test, assessment, mouse model, MTT assays used investigate property, effect, biodegradability biocompatibility Ag-MSNs.Ag-MSNs exhibited not only strong but also excellent activities than Importantly, this nano-adhesive achieved rapid efficient wounds comparison sutures or a model. Ag-MSNs fast behavior caused little cellular even less systemic during healing.Our findings suggest be employed next generation nano-adhesives aesthetic healing.