<p>Combinational phototherapy and hypoxia-activated chemotherapy favoring antitumor immune responses</p>

• DOI: 10.2147/ijn.s203383
• Publication Date: 2019-06-19T21:46:36Z
• Authors: Beibei Ma; Jie Sheng; Ping Wang; Zhongying Jiang; Entomack Borrathybay
• Keywords: Tirapazamine; Immunogenic cell death; Tumor Hypoxia; Hypoxia

Background: Tumor metastasis is responsible for most cancer death worldwide, which lacks curative treatment. Purpose: The objective of this study was to eliminate tumor and control the development metastasis. Methods: Herein, we demonstrated a smart nano-enabled platform, in 2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2h-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium iodide (IR780) tirapazamine (TPZ) were co-loaded poly(ϵ-caprolactone)-poly(ethylene glycol) (PEG-PCL) form versatile nanoparticles (PEG-PCL-IR780-TPZ NPs). Results: intelligence system reflected triggered controlled engineering. Specially, PEG-PCL not only prolonged circulation time IR780 TPZ but also promoted accumulation nanodrugs through enhanced permeability retention (EPR) effect. Moreover, reactive oxygen species (ROS) generated by armed an 808 nm laser irradiation evoked cargo release. Meanwhile, IR780, as mitochondria-targeting phototherapy agent exacerbated hypoxic microenvironment activated accomplishing hypoxia-activated chemotherapy. Most significantly, capable triggering immunogenic cell (ICD) during synergic ICD biomarkers "danger signal" accelerated dendritic cells (DCs) maturation, subsequently toxic T lymphocytes. Conclusion: Eventually, antitumor immune responses stimulated combinational chemotherapy revolutionized current landscape treatment, strikingly inhibiting providing promising prospect clinical application. Keywords: phototherapy, chemotherapy, tirapazamine, responsive,