<p>Dual targeting curcumin loaded alendronate-hyaluronan- octadecanoic acid micelles for improving osteosarcoma therapy</p>

• DOI: 10.2147/ijn.s211981
• Publication Date: 2019-08-08T22:27:37Z
• Authors: Yanhai Xi; Tingwang Jiang; Yinglan Yu; Jiangmin Yu; Mintao Xue; Ning Xu; Jiankun Wen; Weiheng Wang; Hailong He; Yan Shen; Daquan Chen; Xiaojian Ye; Thomas J Webster
• Keywords: Male; 0301 basic medicine; Medicine (General); Curcumin; Polymers; Hyaluronic acid; Proton Magnetic Resonance Spectroscopy; Mice, Nude; Antineoplastic Agents; Bone Neoplasms; 03 medical and health sciences; R5-920; Drug Delivery Systems; International Journal of Nanomedicine; Cell Line, Tumor; Animals; Humans; Hyaluronic Acid; Particle Size; Micelles; Original Research; Drug Carriers; Osteosarcoma; Alendronate; 3. Good health; Drug Liberation; Stearic Acids

Introduction: Curcumin (CUR) is a general ingredient of traditional Chinese medicine, which has potential antitumor effects. However, its use clinically been limited due to low aqueous solubility and bioavailability. In order improve the therapeutic effect CUR on osteosarcoma (i.e., bone cancer), multifunctional micelle was developed here by combining active accumulating ability with tumor CD44 targeting capacity. Methods: The loaded micelles were self-assembled using alendronate-hyaluronic acid-octadecanoic acid (ALN-HA-C18) as an amphiphilic material. obtained characterized for size drug loading. addition, in vitro release behavior investigated under PBS (pH 5.7) medium containing 1% Tween 80 at 37℃. Furthermore, hydroxyapatite (the major inorganic component bone) affinity experiment studied. activity evaluated. Finally, anti-tumor efficiency Results: loading ALN-HA-C18 about 118 ± 3.6 nm 6 1.2%, respectively. released from sustained manner after 12 h. indicated that exhibited high bone. much higher cytotoxic against MG-63 cells compared free CUR. effectively delayed growth properties bearing mice Conclusion: present study suggested novel promising delivery hydrophobic anticancer Keywords: curcumin, alendronate, hyaluronic acid,