<p>Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity</p>

• DOI: 10.2147/ijn.s228715
• Publication Date: 2020-01-23T17:24:12Z
• Authors: Bing Han; Yue Yang; Jinglin Chen; Huan Tang; Yuxin Sun; Zheng Zhang; Zeng Wang; Yan Li; Yao Li; Xue Luan; Qianwen Li; Zhihui Ren; Xiaowei Zhou; Dengli Cong; Zhiyi Liu; Qin Meng; Fei Sun; Jin Pei
• Keywords: Mononuclear phagocyte system

Breast cancer is the leading cause of death in women. Chemotherapy to inhibit proliferation cells considered be most important therapeutic strategy. The development long-circulating PEG and targeting liposomes a major advance drug delivery. However, techniques used liposome preparation mainly involve conventional liposomes, which have short half-life, high concentrations liver spleen reticuloendothelial system, no active targeting.Four kinds paclitaxel were prepared characterized by various analytical techniques. long-term effect was verified fluorescence detection methods vivo vitro. Pharmacokinetic acute toxicity tests conducted ICR mice evaluate safety different preparations. antitumor activity ES-SSL-PTX investigated detail using vitro human breast MCF-7 cell models.ER-targeting had particle size 137.93±1.22 nm an acceptable encapsulation efficiency 88.07±1.25%. best stored at 4°C, stable for up 48 hrs. Cytotoxicity test on demonstrated stronger cytotoxic comparison free paclitaxel. We near-infrared imaging technique confirm that effectively targeted could quickly specifically identify tumor site. Pharmacokinetics experiments carried out. results showed significantly prolong half-life drug, increase its circulation time vivo, improve bioavailability reduce side effects. can pharmacokinetic properties paclitaxel, avoid allergic reaction original solvent, efficacy effects.ES-SSL-PTX has great potential improving treatment cancer, thereby patient prognosis quality life.