<p>In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quantum Dots with Different Surface Modifications</p>

• DOI: 10.2147/ijn.s241332
• Publication Date: 2020-03-19T22:00:23Z
• Authors: Li Li; Yajing Chen; Gaixia Xu; Dongmeng Liu; Zhiwen Yang; Tingting Chen; Xiaomei Wang; Wenxiao Jiang; Dahui Xue; Guimiao Lin
• Keywords: Biodistribution

Introduction: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, potential toxicity InP QDs has not been systematically evaluated. In particular, effects different surface modifications on biodistribution are still unknown, which hinders their further developments. The present study aims to investigate vivo InP/ZnS QDs. Methods: Three kinds with modifications, hQDs (QDs-OH), aQDs (QDs-NH 2 ), cQDs (QDs-COOH) were intravenously injected into BALB/c mice at dosage 2.5 mg/kg BW or 25 BW, respectively. Biodistribution three was determined through cryosection fluorescence microscopy ICP-MS analysis. subsequent histopathology, hematology blood biochemistry evaluated 1, 3, 7, 14 28 days post-injection. Results: These types rapidly distributed major organs mice, mainly liver spleen, lasted for days. No abnormal behavior, weight change organ index observed during whole observation period, except that died Day 1 after treatment. results H&E staining showed no obvious histopathological abnormalities main (including heart, liver, lung, kidney, brain) all surface-functionalized Low concentration exposure hardly caused toxicity, while high could cause some changes hematological parameters biochemical related function cardiac function. More attention needs be paid as high-dose induced death, acute inflammatory reaction slight mice. Conclusion: modification dose can influence biological behavior chemistry should fully considered design InP-based biomedical applications. Keywords: dots, chemistry, vivo, biodistribution, nanotoxicology