Engineering of Neutrophil Membrane Camouflaging Nanoparticles Realizes Targeted Drug Delivery for Amplified Antitumor Therapy

• DOI: 10.2147/ijn.s288636
• Publication Date: 2021-02-14T21:30:49Z
• Authors: Jingshuai Wang; Xuemin Gu; Yiqin Ouyang; Lei Chu; Mengjiao Xu; Kun Wang; Xiaowen Tong
• Keywords: Internalization

Although the neutrophil membrane (NM)-based nanoparticulate delivery system has exhibited rapid advances in tumor targeting stemmed from inherited instinct, antitumor effect requires further improvement due to inefficient cellular internalization absence of specific interactions between NM-coated nanoparticles and cells.Herein, we fabricated drug-paclitaxel loaded NM camouflaging (TNM-PN) modified with necrosis factor-related apoptosis-inducing ligand (TRAIL), favorable for internalization.The results showed that TNM-PN exerted a significant cytotoxicity cells by TRAIL-mediated endocytosis strong adhesion inflamed endothelial vitro. Due TRAIL modification as well adhesive vascular cells, tumors group almost 2-fold higher fluorescence intensities than 3-fold bare nanoparticles, respectively. Significant inhibition survival rates mice were achieved consequence prolonged blood circulations 48 h preferential accumulations, which was ascribed originated immune evasion subsequent excellent research unveiled novel strategy amplifying based on coating nanotechnology boost efficacy.