Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol‐Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities

• DOI: 10.2147/ijn.s289515
• Publication Date: 2021-03-25T23:00:33Z
• Authors: Jie Hu; Juan Luo; Meiling Zhang; Jiashu Wu; Yue Zhang; Hui Kong; Huihua Qu; Guoliang Cheng; Yan Zhao
• Keywords: 0301 basic medicine; Male; Medicine (General); antioxidant; Anti-Inflammatory Agents; Down-Regulation; Nitric Oxide Synthase Type II; 02 engineering and technology; Protective Agents; Antioxidants; Rats, Sprague-Dawley; 03 medical and health sciences; R5-920; International Journal of Nanomedicine; carbon dots; gastroprotection; Animals; Stomach Ulcer; anti-inflammatory; Original Research; 0303 health sciences; Ethanol; Interleukin-6; Tumor Necrosis Factor-alpha; Photoelectron Spectroscopy; NF-kappa B; radix sophorae flavescentis; Carbon; Up-Regulation; 3. Good health; Oxidative Stress; Acute Disease; 0210 nano-technology; Drugs, Chinese Herbal

To explore the effects of Radix Sophorae Flavescentis carbonisata-based carbon dots (RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model.The structure, optical properties, functional groups and elemental composition of RSFC-CDs synthesized by one-step pyrolysis were characterized. The gastric protective effects of RSFC-CDs were evaluated and confirmed by applying a rat model of ethanol-induced acute gastric ulcers. The underlying mechanisms were investigated through the nuclear factor-kappa B (NF-κB) signalling pathway and oxidative stress.RSFC-CDs with a diameter ranging from 2-3 nm mainly showed gastric protective effects by reducing the levels of NF-κB, tumour necrosis factor-α (TNF-α), interleukin (IL)-6, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione (GSH), malondialdehyde (MDA) and inducible nitric oxide synthase (iNOS) to inhibit ethanol-induced inflammation and oxidative stress.RSFC-CDs have anti-inflammatory and anti-oxidative effects, making them promising for application in ethanol-induced gastric injury.