Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

• DOI: 10.2147/ijn.s312074
• Publication Date: 2021-06-02T21:13:00Z
• Authors: Jian Liu; Jinfei Hou; Shaokai Liu; Jialun Li; Muran Zhou; Jiaming Sun; Rongrong Wang
• Keywords: Biocompatibility; Polycaprolactone; Electrospinning; Tissue Adhesion

Effective repair of full-thickness abdominal wall defects requires a patch with sufficient mechanical strength and anti-adhesion characteristics to avoid the formation hernias intra-abdominal complications such as intestinal obstruction fistula. However, patches made from polymers or bio-derived materials may not meet these requirements lack bionic wall.In this study, we report consecutive electrospun method for preparing double-layer structured nanofiber membrane (GO-PCL/CS-PCL) using polycaprolactone (PCL), graphene oxide (GO) chitosan (CS). To expand bio-functions (angiogenesis/reducing reactive oxygen species) (GO-PCL/NAC-CS-PCL), N-acetylcysteine (NAC) was loaded (2×1.5cm) in rat model.The double-layered (GO-PCL/NAC-CS-PCL) showed excellent biocompatibility. After 2 months, rats treated exhibited desired effect no hernia formation, less adhesion (adhesion score: 1.50±0.50, P<0.001) more collagen deposition (percentage deposition: 34.94%±3.31%, P<0.001).The nanomembranes presented study have good anti-hernia effects, well improve microenvironment vivo. It, therefore, holds prospects provides promising key postoperative agent.