One-Step Microfluidic Fabrication of Multi-Responsive Liposomes for Targeted Delivery of Doxorubicin Synergism with Photothermal Effect

• DOI: 10.2147/ijn.s329621
• Publication Date: 2021-11-22T13:10:08Z
• Authors: Songwei Lv; Ran Jing; Xiaowu Liu; Honglei Shi; Yunfeng Shi; Xugang Wang; Xiubo Zhao; Kai Cao; Zhong Lv
• Keywords: Folate receptor; Photothermal effect; Targeted drug delivery; Superparamagnetism

Cancer of the bladder is one most common and life-threatening. Compared with traditional delivery methods, intravesical administration reduces amount drugs required, increases reaching lesion site, minimizes systemic exposure to therapeutic agents. To overcome limitations urinary voiding, low urothelium permeability, intermittent catheterization for large dilution irrigation in bladder, magnetic photothermal-responsive folate receptor-targeted thermal liposomes (FA-TMLs) were designed targeted doxorubicin (DOX) cancer cells.Through a microfluidic mixer chip, nanoparticles (MNPs), gold nanorods (GNRs) DOX encapsulated folate-modified thermosensitive form FA-TMLs@MNPs-GNRs-DOX. DLS, TEM, DSC, hysteresis loop used characterize construction [e-mail]-TMLs@MNPs-GNRs-DOX had size about 230 nm exhibited superparamagnetic properties saturation magnetization 20 emu/g. The loading capacity was as high 0.57 mg/mL. Additionally, drug release FA-TMLs@MNPs-GNRs-DOX could be controlled by temperature change through photothermal effect. A 980 laser beam selectively irradiated on trigger structural changes FA-TMLs, an average 95% released after 3 hours. results cell uptake experiments reveal indicated that able specifically bind folate-receptor-positive cells toxicity tumor cells.The present suggest have promising multifunctional response can act ideal system (DDS) treatment tumors.