Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells

• DOI: 10.2147/ijn.s33575
• Publication Date: 2012-08-13T04:38:38Z
• Authors: Xinquan Jiang; wenjie Zhang; Liu Yan; Jinhua Li; Lianyi Xu; Bin Wei; Xiuli Zhang; Liu; zihui Li; Dongxia Ye
• Keywords: Sawtooth wave

Background: The topography of an implant surface can serve as a powerful signaling cue for attached cells and enhance the quality osseointegration. A series improved surfaces functionalized with nanoscale structures have been fabricated using various methods. Methods: In this study, H 2 O process, we two size-controllable sawtooth-like nanostructures different dimensions on titanium surface. effects nano-sawtooth rat bone marrow mesenchymal stem (BMMSCs) were evaluated without addition osteoinductive chemical factors. Results: These new modifications did not adversely affect cell viability, BMMSCs demonstrated greater increase in proliferation ability than control plate. Furthermore, upregulated expression osteogenic-related genes proteins indicated that promote osteoblastic differentiation BMMSCs. Importantly, large structure resulted greatest responses, including increased adhesion, proliferation, differentiation. Conclusion: enhanced osteogenic abilities suggest potential to induce improvements bone-titanium integration vivo. Our study reveals key role played by fate provides insights into cell-nanostructure relationships related design biomedical surfaces. Keywords: nanotechnology, modification, differentiation, BMMSCs, implants, osseointegration