Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis

• DOI: 10.2147/ijn.s374024
• Publication Date: 2022-10-12T11:30:48Z
• Authors: Lei Qiao; Yue Chen; Xiaofan Song; Xina Dou; Chunlan Xu
• Keywords: Lactobacillus casei; Gut–brain axis

Purpose: The bidirectional communication between the gut and central nervous system mediated by microbiota is closely related to occurrence development of neurodegenerative diseases, including Alzheimer’s disease (AD). Selenium (Se) has been identified as playing a role against AD. Probiotics have beneficial effects on host brain function behavior modulating microbiota-gut-brain axis. Herein, we evaluated protective Lactobacillus casei ATCC 393 ( L. 393) selenium nanoparticles-enriched 393-SeNPs) D-galactose/aluminum chloride-induced AD model mice. Methods: Morris Water Maze (MWM) test was used assess cognitive morphology histopathological changes, antioxidant capacity immune responses in ileum were evaluated. alterations intestinal permeability mice determined using FITC-dextran. Gut composition assessed 16s rRNA sequencing. Results: Thirteen weeks intervention with or 393-SeNPs significantly improved dysfunction, minimized amyloid beta (Aβ) aggregation, hyperphosphorylation TAU protein, prevented neuronal death Akt/cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway. Moreover, compared 393, further effectively mitigated barrier dysfunction improving capacity, regulating response, restoring balance, increasing level short-chain fatty acids neurotransmitters, thereby inhibiting activation microglia protecting neurons from neurotoxicity such oxidative stress neuroinflammation. Conclusion: These findings indicated that targeting axis may therapeutic potential for deficits Thus, anticipate be promising safe Se nutritional supplement use food additive prevent disease. Graphical Abstract: Keywords: disease, microbiota, stress, neuroinflammation