Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

• DOI: 10.2147/ijn.s37984
• Publication Date: 2013-01-24T09:52:51Z
• Authors: Ye Jin; Wen; Sanjay Garg; Zhang; Teng LR; Liu; Zhou
• Keywords: Niosome; Zeta potential; Angle of repose

The aim of this study was to develop an optimal niosomal system deliver Ginkgo biloba extract (GbE) with improved oral bioavailability and replace the conventional GbE tablets.In study, film dispersion-homogenization method used prepare niosomes. resulting niosome suspension freeze-dried or spray-dried improve stability GbE-loaded niosomes were formulated characterized in terms their morphology, particle size, zeta potential, entrapment efficiency, angle repose, differential scanning calorimetry analysis performed. In vitro release vivo distribution studies also carried out.The size delivery prepared Tween 80, Span cholesterol about 141 nm. There a significant difference (P < 0.05) drug efficiency between spray-drying (about 77.5%) freeze-drying 50.1%). revealed no change for at 4°C 25°C after 3 months. suggested that can prolong flavonoid glycosides phosphate-buffered solution (pH 6.8) up 48 hours. showed glycoside content heart, lung, kidney, brain, blood rats treated carrier greater than tablet 0.01). No detected brain tissue given tablets, but they niosomes.Niosomes are promising brain.