Ginsenoside Rh2-Based Multifunctional Liposomes for Advanced Breast Cancer Therapy

• DOI: 10.2147/ijn.s437733
• Publication Date: 2024-03-19T13:15:06Z
• Authors: Chao Hong; Anni Wang; Jiaxuan Xia; Jianming Liang; Ying Zhu; Dan Wang; Huaxing Zhan; Chunbo Feng; Xinnan Jiang; Junjie Pan; Jianxin Wang
• Keywords: Medicine (General); 0303 health sciences; 03 medical and health sciences; R5-920; tumor-associated fibroblast; tumor microenvironment; chemotherapy; nanomedicine; Original Research

Background: Most solid tumors are not diagnosed and treated until the advanced stage, in which have shaped mature self-protective power, leading to off-target drugs nanomedicines. In present studies, we established a more realistic large tumor model test antitumor activity of multifunctional ginsenoside Rh2-based liposome system (Rh2-lipo) on breast cancer. Methods: Both cholesterol PEG were substituted by Rh2 prepare Rh2-lipo using ethanol-water characterized. The effects cell uptake, penetration spheroid, cytotoxicity assay was investigated with 4T1 cancer cells L929 fibroblast cells. orthotopic-bearing study targeting effect inhibitory paclitaxel loaded (PTX-Rh2-lipo) tumors. Results: exhibit many advantages that address limitations current formulations against tumors, such as enhanced uptake TAFs cells, high capacity, TAFs, normalization vessel network, depletion stromal collagen. vivo study, PTX-Rh2-lipo effectively inhibiting growth outperformed most reported PTX formulations, including Lipusu ® Abraxane . Conclusion: improved drug delivery efficiency efficacy cancer, offers novel promising platform for therapy. Keywords: nanomedicine, microenvironment, chemotherapy, tumor-associated