Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy

• DOI: 10.2147/ijn.s450018
• Publication Date: 2024-02-21T04:40:07Z
• Authors: Yi Jiang; Xiaoming Liao; Wei Tang; Chunyu Huang; You Pan; Shipeng Ning
• Keywords: Sonodynamic therapy

Introduction: The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy radiotherapy (RT). Efficient elimination potential CSCs is crucial for enhancing effectiveness RT. Methods: In this study, we developed a biomimetic hybrid nano-system (PMC) composed MnCO 3 as inner core and platelet membrane (PM) outer shell. By exploiting specific recognition properties surface proteins, PMC enables precise targeting CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity eradicating Subsequent RT effectively eliminates common tumor cells. Results: Both in vitro cell experiments vivo animal studies demonstrate that SDT mediated by synergistically enhances to selectively combat while inhibiting growth without noticeable side effects. Discussion: Our findings offer novel insights safety profiles Keywords: clearance, radiosensitization, membrane, sonodynamic therapy,