Engineering Ag-Decorated Graphene Oxide Nano-Photothermal Platforms with Enhanced Antibacterial Properties for Promoting Infectious Wound Healing

• DOI: 10.2147/ijn.s474536
• Publication Date: 2024-08-30T05:30:14Z
• Authors: Zhiwei Sun; Xiangru Chen; Fang Miao; Na Meng; Keqiang Hu; Shaotang Xiong; Ximing Peng; Liya Ma; Chuchao Zhou; Yanqing Yang
• Keywords: Photothermal effect

Introduction: Graphene oxide (GO) nanoparticles have emerged as a compelling photothermal agent (PHTA) in the realm of antibacterial therapy, owing to their cost-effectiveness, facile synthesis, and remarkable photostability.Nevertheless, therapeutic efficacy GO is commonly hindered by inherent drawback low conversion efficiency (PCE).Methods: Herein, we engineer Ag/GO-GelMA platform growing Ag on surface encapsulating Ag/GO into GelMA hydrogels.Results: The resulting demonstrates significantly enhanced PCE (47.6%), surpassing that pure (11.8%) more than fourfold.As expected, platform, which was designed integrate benefits (high PCE) hydrogel (slowly releasing + exert an effect), has been shown exhibit exceptional efficacy.Furthermore, transcriptome analyses demonstrated could down-regulate pathways linked inflammation (the MAPK PI3K-Akt pathways) had ability promote cell migration.Discussion: Taken together, this study presents design potent (Ag/GO-GelMA) aimed at enhancing healing infectious wounds.The utilizes handy method enhance GO, thereby making notable progress utilization nano-PHTAs.