Exosomes Derived from Antler Mesenchymal Stem Cells Promote Wound Healing by miR-21-5p/STAT3 Axis

• DOI: 10.2147/ijn.s481044
• Publication Date: 2024-11-04T04:15:11Z
• Authors: Deshuang Meng; Yingrui Li; Ze Chen; Jia Guo; Min Yang; Yinghua Peng
• Keywords: Antler; Exosome

Background: Deer antlers, unique among mammalian organs for their ability to regenerate annually without scar formation, provide an innovative model regenerative medicine. This study explored the potential of exosomes derived from antler mesenchymal stem cells (AMSC-Exo) enhance skin wound healing. Methods: We proliferation, migration and angiogenesis effects AMSC-Exo on HaCaT HUVEC cells. To investigate repairing effect AMSC-Exo, we established a full-thickness injury mouse model. Then thickness, epidermis, collagen fibers, CD31 expressions were tested by H&E staining, Masson's trichrome staining immunofluorescence experiments. MiRNA omics analysis was conducted explore mechanism in repairing. Results: stimulated proliferation cells, accelerated In model, regulated extracellular matrix facilitating conversion type III I, restoring epidermal thickness normal state aberrant hyperplasia. Notably, enhanced quality healing with increased vascularization reduced formation. MiRNAs especially through miR-21-5p/STAT3 signaling pathway, played crucial role these processes. Conclusion: underscores efficacy treating wounds, suggesting new approach enhancing repair regeneration. Keywords: deer antler, exosomes, microRNA,