Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function

• DOI: 10.2147/ijn.s488532
• Publication Date: 2024-11-18T15:45:12Z
• Authors: Pilong Shi; Yuetong Sha; Xinran Wang; Tao Yang; Jiawei Wu; Jiajun Zhou; Kai Liu; Xue Guan; Song Wang; Yongsheng Liu; Jingquan Gao; Hongli Sun; Tao Ban; Yonggang Cao
• Keywords: mdm2; lutein; Medicine (General); 0303 health sciences; 03 medical and health sciences; R5-920; ros; myocardial ischemia-reperfusion injury; ndufs1; ferroptosis; Original Research

Myocardial ischemia-reperfusion injury (MI/RI) is associated with increased oxidative damage and mitochondrial dysfunction, resulting in an elevated risk of mortality. MI/RI may be alleviated by protecting cardiomyocytes from stress. Lutein, which belongs to a class carotenoids, has proven effective cardiovascular disease treatment due its remarkable antioxidant properties, but application limited poor stability low bioavailability vivo.