Electrosprayed core–shell solid dispersions of acyclovir fabricated using an epoxy- coated concentric spray head

• DOI: 10.2147/ijn.s59516
• Publication Date: 2014-04-17T01:31:14Z
• Authors: Deng-Guang Yu; Zhe-Peng Liu; Lei Cui; Zhuan-xia Zhao; Lan Chen
• Keywords: Polyvinylpyrrolidone; Sodium dodecyl sulfate

Abstract: A novel structural solid dispersion (SD) taking the form of core–shell microparticles for poorly water-soluble drugs is reported first time. Using polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix, SDs were fabricated using coaxial electrospraying (characterized by an epoxy-coated concentric spray head), although core fluids unprocessable one-fluid electrospraying. Through manipulating flow rates drug-loaded solutions, two types with tunable drug contents prepared. They had average diameters 1.36±0.67 and 1.74±0.58 µm, essentially combination nanocomposites active ingredient acyclovir (ACY) distributed in inner core, sweeter sucralose transmembrane enhancer sodium dodecyl sulfate localized outer shell. Differential scanning calorimetry X-ray diffraction results demonstrated that ACY, sulfate, well PVP matrix amorphous state because favorable second-order interactions. In vitro dissolution permeation studies showed microparticle rapidly freed ACY within 1 minute promoted nearly eightfold increases rate across sublingual mucosa compared raw powders. Keywords: microparticle, dispersion, electrospraying, drug, head