Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

• DOI: 10.2147/ijn.s75706
• Publication Date: 2015-01-20T01:06:36Z
• Authors: Jiang Wu; Yicheng Cheng; Xianghui Zhao; Xianghui Liu; Weige Sun; Huifang Ren; Bo Gao
• Keywords: Titanium; 0301 basic medicine; Staphylococcus aureus; Osteoblasts; Polymers; Polyesters; Staphylococcal Infections; Anti-Bacterial Agents; Rats; 3. Good health; 03 medical and health sciences; Coated Materials, Biocompatible; International Journal of Nanomedicine; Animals; Nanoparticles; Lactic Acid; Furans; Original Research; Cell Proliferation

Abstract: Titanium implants have been widely used for many medical applications, but bacterial infection after implant surgery remains one of the most common and intractable complications. To this end, long-term antibacterial ability surface is highly desirable to prevent implant-associated infection. In study, a novel coating containing new agent, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone loaded poly(L-lactic acid) nanoparticles, was fabricated on microarc-oxidized titanium purpose. The produced unique inhibition zone against Staphylococcus aureus throughout 60-day study period, which normally long enough around in early intermediate stages. rate adherent S. about 100% first 10 days constantly remained over 90% following 20 days. Fluorescence staining also confirmed excellent coating. Moreover, vitro experiments showed an enhanced osteoblast adhesion proliferation coating, more notable cell spread observed at stage. It therefore concluded that exhibits relatively biological performance, potential promising strategy Keywords: microarc oxidation, osteoblasts