Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

• DOI: 10.2147/ijn.s81097
• Publication Date: 2015-03-25T04:06:43Z
• Authors: Oleh Taratula; Olena Taratula; Mehulkumar Patel; Canan Schumann; Michael Naleway; Huixin He; Addison Pang
• Keywords: Biocompatibility; Fluorescence-lifetime imaging microscopy; Cyanine

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy Olena Taratula,1 Mehulkumar Patel,2 Canan Schumann,1 Michael A Naleway,1 Addison J Pang,1 Huixin He,2 Oleh Taratula1 1Department of Pharmaceutical Sciences, College Pharmacy, Oregon State University, Portland, OR, USA; 2Department Chemistry, Rutgers University-Newark, Newark, NJ, USA Abstract: We report a novel cancer-targeted nanomedicine platform for imaging and prospect future treatment unresected ovarian cancer tumors by intraoperative multimodal phototherapy. To develop the required theranostic system, low-oxygen nanosheets were chemically modified with polypropylenimine dendrimers loaded phthalocyanine (Pc) as photosensitizer. Such molecular design prevents fluorescence quenching Pc nanosheets, providing possibility imaging. Furthermore, developed was conjugated poly(ethylene glycol), to improve biocompatibility, luteinizing hormone-releasing hormone (LHRH) peptide, tumor-targeted delivery. Notably, low-power near-infrared (NIR) irradiation single wavelength used both heat generation (photothermal therapy [PTT]) reactive oxygen species (ROS)-production (photodynamic [PDT]). The resulted in an enhanced destruction cells, killing efficacy 90%–95% at low dosages, presumably conferring cytotoxicity synergistic effects generated ROS mild hyperthermia. An animal study confirmed that into can be employed NIR agent imaging-guided drug Hence, newly Pc-graphene has significant potential effective probe Keywords: phthalocyanine, photothermal therapy, photodynamic theranostic&nbsp