Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts

• DOI: 10.2147/ijn.s81451
• Publication Date: 2015-07-29T00:05:56Z
• Authors: Rui Fang; Shupei Qiao; Yi Liu; Xiongbiao Chen; Bing Song; Qingyuan Meng; Xiaolu Hou; Weiming Tian
• Keywords: 0301 basic medicine; Medicine (General); Drug Carriers; Indoles; Myocardial Infarction; Hydrogel, Polyethylene Glycol Dimethacrylate; Rats; 12. Responsible consumption; 03 medical and health sciences; R5-920; International Journal of Nanomedicine; Oximes; Animals; Regeneration; Myocytes, Cardiac; Insulin-Like Growth Factor I; Original Research

Abstract: Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival proliferation. However, their delivery for sustained release MI-affected areas has proved to be challenging. In the current research, we present a study on co-delivery BIO IGF-1 hybrid hydrogel system simulate an MI rat model. Both were efficiently encapsulated gelatin nanoparticles, which later cross-linked with oxidized alginate form novel system. The vivo results indicated could enhance revascularization around sites, allowing improved function. Taken together, concluded co-deliver thus function by promoting revascularization. Keywords: infarction, nanoparticle, proliferation, injectable