Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

• DOI: 10.2147/ijn.s85999
• Publication Date: 2015-07-22T02:05:06Z
• Authors: Ai-Zheng Chen; Lin-qing Chen; Shi-bin Wang; Ya-qiong Wang; Jun-zhe Zha
• Keywords: Fibroin

Abstract: A synergistic approach by the combination of magnetic nanoparticles with an alternating field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin were prepared using suspension-enhanced dispersion supercritical CO 2 . The physiochemical properties characterized. In vitro studies on permeation across skin performed under different fields in comparison passive diffusion. flux enhancement factor found to increase a stationary field, while enhanced more effectively; and fields, which has massage-like effect skin, achieved best result. mechanistic attenuated total reflection Fourier-transform infrared spectroscopy demonstrate that can change ordered structure stratum corneum lipid bilayers from gel lipid-crystalline state, fluidity lipids, thus enhancing penetration. Compared other groups, fluorescence signal bigger area detected deeper regions also reveals simulated massage could enhance increasing follicular transport. stationary/alternating potential effective delivery. Keywords: nanoparticles, magnetophoresis, fluid, methotrexate